Van de Beek sealed a temporary move to Everton on deadline day while Jesse Lingard's move to Newcastle was blocked, meaning three players left the club on loan across January after Martial joined Sevilla and Amad joined Rangers earlier in the window.
Ahead of the window, the Manchester Evening News understood new signings were unlikely in January and United signed nobody, as expected. The club's priority is signing a new midfielder and United are certain to be active in the transfer market in the summer.
United return to Premier League action next week and securing Champions League football is now the target.
But what is United's strongest line-up after the January window? We've taken a closer look.
David de Gea has been United's best player this season and he remains one of the first names on Ralf Rangnick's team sheet. Dean Henderson was desperate to leave United on loan in search of minutes in January but no such move materialised.
While Henderson will continue to be frustrated at his lack of game time, he'll keep on De Gea on his toes in training.
Diogo Dalot's United career has finally begun to progress. The full-back offers United another dimension in attacks compared to Aaron Wan-Bissaka and he's also capable defensively. He seems set to start the majority of the remaining games of the season.
On the other side of the defence, Alex Telles hasn't convinced in the fashion of Dalot and Luke Shaw can regain his starting spot.
There were glimmers of a return to form for Harry Maguire against Aston Villa and he can start with the superb Raphael Varane.
Which did you think of United's January business? Let us know your thoughts in the comments below.
Jadon Sancho returned to United training on Monday afternoon and he can start the right side. Sancho was appearing to begin to deliver on his promise following Ole Gunnar Solskjaer's sacking and he has a point to prove for the remainder of the season.
It will be a tough decision for Rangnick to choose between Anthony Elanga and Marcus Rashford. The latter scored two goals in two substitute appearances before the break, however, Elanga has been brilliant and a real breath of fresh air on the left.
Elanga might get the nod to start for now, but the healthy competition between the pair can only be good news for United.
Cristiano Ronaldo is an inevitable starter and he will continue to lead United's attack this term.
Strongest XI: De Gea, Shaw, Maguire, Varane, Dalot, McTominay, Fernandes, Fred, Elanga, Ronaldo, Sancho.
